It is an autosomal recessive disorder. It occurs equally in males and females, and found in all ethnic groups; it can affect all systems of the body, and many patients eventually develop acute myelogenous leukemia at an early age; they also develop a variety of other head, neck, gynecological and or gastrointestinal cancers; the patient can be cured of the FA blood problem by having a successful bone marrow transplant, but must still have regular examinations to watch for signs of cancer. A couple (both with FA) who have already had one child with FA decide that they would like to have another child.
a.) What was the genotype of the child with FA?
b.) What is the probability that their next child will have FA?
14
Sep

Homozygous recessive
100%
Both parents must donate the damaged gene since their homozygous for it each being afflicted with this autosomal recessive disease. Therefore, they will each give the only diseased alleles of the gene to all of their children making them homozygous for the recessive allele and thus diseased.