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Dr. Nelson Mane Talks About Another Factor You May not be Aware of With Regard to Autism

Autism as defined by NINDS is “What is Autism”.

What is autism?

Autism (sometimes called “classical autism”) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).   Autism is characterized by impaired social interaction, problems with verbal and nonverbal communication, and unusual, repetitive, or severely limited activities and interests.  Other ASDs include Asperger syndrome, Rett syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (usually referred to as PDD-NOS).  Experts estimate that three to six children out of every 1,000 will have autism.  Males are four times more likely to have autism than females.  – National Institute of Neurological Disorders and Stroke.

Most agree that the cause of Autism Spectrum Disorders is multi-factoral and that one specific cause has not been identified. As such, those of us who treat children with ASD are always looking for any other possible cause that can be ruled out in order to make the most effective use of the doctor’s treatment and the patient’s family’s energy. Many parents are not aware that Vitamin D deficiency is a possible factor which may influence the development, treatment and potential improvement of these children.Let’s go to the scientific literature.

Autism and vitamin D

Atascadero State Hospital, Psychiatry, 10333 El Camino Real, Atascadero, CA 93423, United States.

Any theory of autism’s etiology must take into account its strong genetic basis while explaining its striking epidemiology. The apparent increase in the prevalence of autism over the last 20 years corresponds with increasing medical advice to avoid the sun, advice that has probably lowered vitamin D levels and would theoretically greatly lower activated vitamin D (calcitriol) levels in developing brains. Animal data has repeatedly shown that severe vitamin D deficiency during gestation dysregulates dozens of proteins involved in brain development and leads to rat pups with increased brain size and enlarged ventricles, abnormalities similar to those found in autistic children. Children with the Williams Syndrome, who can have greatly elevated calcitriol levels in early infancy, usually have phenotypes that are the opposite of autism. Children with vitamin D deficient rickets have several autistic markers that apparently disappear with high-dose vitamin D treatment. Estrogen and testosterone have very different effects on calcitriol’s metabolism, differences that may explain the striking male/female sex ratios in autism. Calcitriol down-regulates production of inflammatory cytokines in the brain, cytokines that have been associated with autism. Consumption of vitamin D containing fish during pregnancy reduces autistic symptoms in offspring. Autism is more common in areas of impaired UVB penetration such as poleward latitudes, urban areas, areas with high air pollution, and areas of high precipitation. Autism is more common in dark-skinned persons and severe maternal vitamin D deficiency is exceptionally common the dark-skinned. Conclusion: simple Gaussian distributions of the enzyme that activates neural calcitriol combined with widespread gestational and/or early childhood vitamin D deficiency may explain both the genetics and epidemiology of autism. If so, much of the disease is iatrogenic, brought on by medical advice to avoid the sun. Several types of studies could easily test the theory.

PMID: 17920208 [PubMed - indexed for MEDLINE]

Dr. Mane offers one on one consultations as well as Group Seminars  for parents and children who suffer from Autism Spectrum Disorders.  If you are interested in scheduling a consultation or to attend a seminar please call 813-935-4744. 

For more information about Dr. Nelson Mane, D.C. and his treatment approach for ASD go to http://www.manecenter.com/ADHD.htm. 

 

Autism – Signs and Symptoms of Autism

Autism is a severe developmental disorder that begins at birth or within the first two-and-a-half years of life. Most autistic children are perfectly normal in appearance, but spend their time engaged in puzzling and disturbing behaviors which are markedly different from those of typical children. Less severe cases may be diagnosed with Pervasive Developmental Disorder (PDD) or with Asperger’s Syndrome (these children typically have normal speech, but they have many “autistic” social and behavioral problems).

Autism (sometimes called “classical autism”) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs). Autism is characterized by impaired social interaction, problems with verbal and nonverbal communication, and unusual, repetitive, or severely limited activities and interests.

Signs and Symptoms of Autism

The list of symptoms and behaviors associated with autism is long, and each affected person expresses his or her own combination of these behaviors. None of these clinical features is common to all people with autism, and many are occasionally exhibited by people who are not autistic.

Autistic infants may act relatively normal during their first few months of life before becoming less responsive to their parents and other stimuli. They may have difficulty with feeding or toilet training; may not smile in recognition of their parents’ faces, and may put up resistance to being cuddled.

An autistic child has poor judgment and is therefore always at risk for danger. For instance, an autistic child may run into a busy street without any sign of fear.

During adolescence, some children with autism may become depressed or experience behavioral problems. Parents of these children should be ready to adjust treatment for their child as needed.

Autistic persons often exhibit a variety of repetitive, abnormal behaviors. There may also be a hypersensitivity to sensory input through vision, hearing, or touch (tactile). As a result, there may be an extreme intolerance to loud noises or crowds, visual stimulation, or things that are felt.

Young children with autism also have a hard time sharing experiences with others. When someone reads to them, for example, they’re unlikely to point at pictures in the book. This early-developing social skill is crucial to later language and social development.

Sleep problems are known to be more common in children with developmental disabilities, and there is some evidence that children with ASD are more likely to have even more sleep problems than those with other developmental disabilities; autistic children may experience problems including difficulty in falling asleep, frequent nocturnal awakenings, and early morning awakenings. Dominick et al. found that about two-thirds of children with ASD had a history of sleep problems

Treatment for Autism

Diet: Some children with autism appear to respond to a gluten-free or a casein-free diet. Gluten is found in foods containing wheat, rye, and barley. Casein is found in milk, cheese, and other dairy products. Not all experts agree that dietary changes will make a difference, and not all reports studying this method have shown positive results.

Behavioral and communication therapies: Many programs have been developed to address the range of social, language and behavioral difficulties associated with autism. Some programs focus on reducing problem behaviors and teaching new skills. Other programs focus on teaching children how to act in social situations or how to communicate better with other people.

Communication therapy: Communication therapy is used to treat autistic patients who are unable to communicate verbally, or to initiate language development in young children with the disorder. Speech therapy may be used to help patients gain the ability to speak.

Medicine: Medicines are often used to treat behavior or emotional problems that people with autism may have. These include hyperactivity, impulsiveness, attention problems, irritability, mood swings, outbursts, tantrums, aggression, extreme compulsions that the child finds it impossible to suppress, sleep difficulty, and anxiety. Currently, only risperidone is approved for treatment of children ages 5-16 with irritability and aggression associated with autism.

Autism

AUTISM

Autism starts before a child turns to three years. It is a disorder in the brain development which weakens the social interaction and communication. Autism causes restricted and repetitive behavior. Autism is a hereditary disorder even though the genetics of autism are complex and it is unclear which genes are responsible. Autism is associated with agents which cause birth defects in rare cases. Other possible causes of autism are childhood vaccines which are controversial and the vaccine hypotheses lack convincing scientific evidence. According to the experts out of 1000 children 3-6 children will have autism. Male are four times more to have autism than females.

Symptoms

The occurrence of autism is not known and it affects many parts of the brain. In the first two years of the child’s life, parents usually notice the signs of autism. Autism is characterized by three distinctive behaviors. The autistic children have difficulties with social interaction, problems with verbal and non verbal communication, and repetitive behaviors or narrow, obsessive interests. There is a reduced sensitivity of pain, but are more sensitive to sound, touch or other sensory stimulation. These reactions may contribute to the behavioral symptoms such as a resistance to being cuddled or hugged. There is no cure for autism but treatment can help. The early behavioral and cognitive interference can help them to develop self-care, social and communication. An infant with autism may be non responsive to people or focus intently on one item by excluding others for a long period of time. With this disorder few children live independently after reaching adulthood and some of them become successful. Some people believe that autism is a condition than a disorder.

Autism children have speech problems, they might not look in to the eyes when talk to them. Before they can pay attention they may have to line up their pencils, these children will say the same sentence again and again. To tell that they are happy they flap their arms or they might hurt themselves if they are not. Some people never learn to talk. They lack empathy. The autistic children cannot interpret the thoughts and feelings of others and also cannot understand the tone of voice and facial expressions. The autistic people have different symptoms and because this it is known as spectrum disorder. The milder version of this disorder is Asperger syndrome. The disorder lasts throughout a person’s life time. Autism shares numerous signs with Rett syndrome and childhood disintegrative disorder. Asperger’s syndrome does not have any delay in the language development. Autistic children are at a higher risk for some co-existing conditions such as fragile X syndrome which causes mental retardation, tuberous sclerosis in which the tumors grow on the brain, epileptic seizures, Tourette syndrome, disabilities in learning and attention deficit disorder. By the time autistic children reach adulthood about 20 to 30% of children develop epilepsy for the reasons unknown. Also schizophrenic people may show some autistic-like behavior but the symptoms do not appear until the late teens or early adulthood. The Schizophrenic people also have hallucinations and delusions which are not found in autism.

Diagnose

Based on the IQ autism is sometimes divided in to the low, medium and high functioning autism. The child affected by autism will show less attention to social stimuli, smile and look at others less often and very rarely respond to their own name. The severity and symptoms of autism may go unrecognized mainly in mildly affected children or when it is covered by more weakening handicaps. Doctors depend on a group of behaviors for diagnosing autism. These behaviors are:

(1) Unable to make friends with peers

(2) Unable to initiate or to continue a conversation with others.

(3) Absence of imaginative and social play.

(4) Unusual, typecast, repetitive use of language.

(5) Preoccupation with certain subjects or objects.

(6) Rigid devotion to certain routines or rituals.

With help of a questionnaire or any other screening instrument doctors assemble information about the child’s development and behavior. Some screening depends on the parent observations and some others on a combination of parent and doctor observations. If there is an indication or possibility of autism, the doctors will ask for more comprehensive evaluation. As autism is a complex disorder a combined evaluation is needed with a multidisciplinary team including psychologist, neurologist, psychiatrist, speech therapist and other expert in diagnosing the children with ASDs. Girls with autism may be suffering from Rett syndrome, a sex-linked genetic disorder described by social withdrawal, deteriorated language skills and hand wringing.

Treatment

Autism cannot be cured. But according to the experts the earlier intervention can make them to cope up with the day-to-day life. Structured and skill oriented training sessions to help children develop social and language skills. Counseling for parents and siblings of autistic children can help the families to cope with the challenges of living with an autistic child. To handle symptoms of anxiety, depression or obsessive compulsive disorder doctors often prescribe anti depressant medications. To treat severe behavioral problems anti-psychotic medicines are used. With one or more of the anti-convulsant drugs seizures can be treated. To reduce impulsiveness and hyperactivity stimulant drugs are some times used effectively. There are several therapies which are controversial and parents should be aware of that before taking in to consideration any of these treatments.